The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

A literature review (up to December 2022) published in Healthcare in June 2023 by Ferrari, Magni, Bosco, Biancotto, Zorzato, Laganà, Chiantera, Raffaelli, Franchi, Uccella, and Garzon explores the connection between diet and nutrition and how they are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. This piece aims to clarify the effects of micronutrients, minerals, and vitamins on the history of HPV infection and the development of cervical cancer. The review includes studies that have, as their primary objective, the evaluation of dietary supplements, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients demonstrated a potential protective role against cervical cancer by intervening in different stages of the natural history of HPV infection, development of cervical dysplasia, and invasive disease. Healthcare providers should be aware of and incorporate the literature evidence in counseling, although the low quality of evidence provided by available studies recommends further well-designed investigations to give clear indications for clinical practice. Read more here.