Untreated CIN 2 and subsequent risk of cervical cancer: population based cohort study

This population-based cohort study in Denmark, published in BMJ by Dyhr Lycke, Kahlert, et. al, explores the long-term risk of cervical cancer in women diagnosed with untreated cervical intraepithelial neoplasia grade 2 (CIN2) compared to those immediately treated with large loop excision of the transformation zone (LLETZ). The cohort of 27,524 women diagnosed between 1998-2020 revealed that while the cumulative risk of cervical cancer was initially comparable between the two groups during the active surveillance period, it increased significantly in the active surveillance group after two years, reaching 2.65% after 20 years. In contrast, the risk remained stable at 0.76% in the LLETZ group. The study emphasizes the importance of continued follow-up for women undergoing active surveillance for CIN2 due to the elevated long-term risk of cervical cancer. Read more here.